Evaluation of Personalised Canine Electromechanical Models
نویسندگان
چکیده
Cardiac modelling aims at understanding cardiac diseases and predicting cardiac responses to therapies. By generating the electrical propagation, the contraction and the mechanical response, we are able to simulate cardiac motion from non-invasive imaging techniques. Four healthy canine clinical data (left ventricles) were provided by the STACOM’2014 challenge. Our study is based on Bestel-Clement-Sorine mechanical modelling, while the electrophysiological phenomena is driven by an Eikonal model. Our model has been calibrated by a quantitative sensitivity study as well as a personalized automatic calibration. Results and comparison with clinical measures are shown in terms of left ventricular volume, flow, pressure and ejection fraction.
منابع مشابه
Propagation of Myocardial Fibre Architecture Uncertainty on Electromechanical Model Parameter Estimation: A Case Study
Computer models of the heart are of increasing interest for clinical applications due to their discriminative and predictive power. However the personalisation step to go from a generic model to a patientspecific one is still a scientific challenge. In particular it is still difficult to quantify the uncertainty on the estimated parameters and predicted values. In this manuscript we present a n...
متن کاملMechanistic insight into prolonged electromechanical delay in dyssynchronous heart failure: a computational study.
In addition to the left bundle branch block type of electrical activation, there are further remodeling aspects associated with dyssynchronous heart failure (HF) that affect the electromechanical behavior of the heart. Among the most important are altered ventricular structure (both geometry and fiber/sheet orientation), abnormal Ca(2+) handling, slowed conduction, and reduced wall stiffness. I...
متن کاملVirtual Pulmonary Valve Replacement Interventions with a Personalised Cardiac Electromechanical Model
Pulmonary valve replacement (PVR) is a pivotal treatment for patients who suffer from chronic pulmonary valve regurgitations. Two PVR techniques are becoming prevalent: a minimally invasive approach and an open-heart surgery with direct right ventricle volume reduction. However, there is no common agreement about the postoperative outcomes of these PVR techniques and choosing the right therapy ...
متن کاملTechnical Note: A 3-D rendering algorithm for electromechanical wave imaging of a beating heart.
PURPOSE Arrhythmias can be treated by ablating the heart tissue in the regions of abnormal contraction. The current clinical standard provides electroanatomic 3-D maps to visualize the electrical activation and locate the arrhythmogenic sources. However, the procedure is time-consuming and invasive. Electromechanical wave imaging is an ultrasound-based noninvasive technique that can provide 2-D...
متن کاملPersonalised Electromechanical Model of the Heart for the Prediction of the Acute Effects of Cardiac Resynchronisation Therapy
Cardiac resynchronisation therapy (CRT) has been shown to be an effective adjunctive treatment for patients with dyssynchronous ventricular contraction and symptoms of the heart failure. However, clinical trials have also demonstrated that up to 30% of patients may be classified as non-responders. In this article, we present how the personalisation of an electromechanical model of the myocardiu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014